Center for Arthritis & Autoimmune Diseases

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New Medications Being Studied

Currently Available Research Trials for Osteoarthritis

1. A study to compare the incidence of clinically significant upper GI adverse events associated with celecoxib to that of ibuprofen in patients with Osteoarthritis (OA) or Rheumatiod Arthritis (RA).


A 52-week study comparing the incidence of upper gastrointestinal (GI) events of a new type of non-steroidal anti-inflammatory drug (NSAID), Celecoxib to that of a currently available NSAID, Ibuprofen (motrin). COX-2 is a new classification of NSAIDs that is anticipated to provide analgesic and anti-inflammatory activity without the incidence of as much GI events.


*Opened to patients with any type of RA (RF+ or RF-) that has been diagnosed for at least 3 months

*Must be willing to participate in this study for 52 weeks. Patients will be seen every 13 weeks and be given a stipend of $150 at the conclusion of their participation in this study

*Must not have a prior medical history of gastric or duodenal surgery or be taking anti-ulcer medications on a regular basis (medicines like pepcid, zantac, tagamet, prilosec etc.).

2. Randomized controlled multi-center double-blind crossover clinical trial to compare the efficacy and safety of arthrotec to acetaminophen in patients with osteoarthritis of the hip or knee.


A 12-week study to compare the effectiveness and safety of a currently available medication, Arthrotec (diclofenac (Voltaren) with a stomach-protecting medicine misoprostol (cytotec)) to Acetaminophen (tylenol). Evaluations of overall pain-relief and the incidence of stomach upset will be evaluated.


*Must be 40 or older

*Must have knee or hip osteoarthritis. X-RAYS WILL BE DONE IF NONE HAVE BEEN DONE IN THE PAST 6 MONTHS

*NO prior medical history of a serious gastrointestinal (GI) event (peptic ulcer, GI bleed or perforation) or bleeding disorder

*Must not be taking more than 325 mg of aspirin (1 regular aspirin) per day, on any anticoagulants (coumadin, ticlid, plavix, etc.) or be taking lithium.

*NO intra-articular steroidal injections into the affected joint in the 6 weeks prior to study entry