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Basic & Clinical ResearchFor Rheumatoid Osteoarthritis: ACTA TRIAL Randomized Controlled Multi-center Double-Blind Crossover Clinical Trial to Compare the Efficacy and Safety of Arthrotec 75 mg bid to Acetaminophen 4,000 mg per day in Patients with Osteoarthritis of the Hip or Knee. Inclusion Criteria:  M/F 40 years old and above
Documented history of Stage 11, 111, or IV Knee OA. X-Rays will be done done within 6 months o enrollment.
Exclusion Criteria: Hx of intolerance to diclofenace, misoprostol, or acetaminophen
Known hypersensitivity of ASA or NSAIDs
Prior hx of a serious GI event (i.e.,peptic ulcer, GI perforation or hemorrhage)
Hx of a bleeding disorder or receiving concomitant therapy with >325mg ASA, anticoagulants, or lithium
No intra-articular steroidal injections into affected joint for 6 wks. prior enrollment
Tests positive for occult blood in the stool
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