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Basic & Clinical Research
For Rheumatoid Arthritis and Osteoarthritis: A Multicenter, Double-Blind, Parallel Group Study Comparing the Incidence of Clinically Significant Upper GI Adverse Events Associated with Celecoxib (SC-58635) 400 mg bid to that of Ibuprofen 800 mg tid in Patients with OA or RA ***Opened to any type of OA (hip, knee, spine, shoulder, foot etc.) or RA (RF +/ RF-)*** Inclusion Criteria:  Documented Diagnosis of RA or OA for at least 3 months requiring chronic NSAID use
Must be willing to participate for the duration of the study (52 weeks)
Exclusion Criteria: No active GI disease
No history of gastric or duodenal surgery other than simple oversew of an ulcer or perforation
NO regular use of anti-ulcer medications (H-2 antagonists, proton pump inhibitors, sucralfate and misoprostol) Short-term use of antacids is permitted.
NO active malignancy (history of malignancy acceptable if no evidence of recurrence in 5 years or greater)
NO hypersensitivity to COX-2 inhibitors, sulfonamides, or ibuprofen
***Patients will be paid $150 for participation***
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